The challenge addressed by this project is the controlled self-assembly of the functioning devices at nanoscale. Self-assembling DNA cassettes, crystals and origami are used as building blocks to assemble 2D and 3D architectures. Redox and pH regulated nano optical modulators were developed through our efforts, innovations which have gained much attention in the scientific community. The project employs a variety of tools drawn from synthetic chemistry structural biology and materials science. We continue to explore and develop DNA-organic constructs with novel properties (quantum, optical and electronic) and materials (organic/conducting polymers, fluorescence molecules and graphene nano-ribbons), that may have lead to applications in electronics, quantum computing and nanotechnology.